About Diprivan

Diprivan® (propofol) is a short-acting intravenous anaesthetic agent suitable for both induction and maintenance of general anaesthesia, ICU sedation and sedation during diagnostic or surgical procedures.

It is a white aquaeous isotonic oil in water emulsion for i.v. injection with propofol (2,6 di-isopropylphenol) as its active ingredient.
Fast on-off action for induction and maintenance

 Rapid induction [1-3]
 Prompt, clear-headed recovery [1]
 Low incidence of PONV[1]
 Easy to control the level of anaesthesia or sedation[4]

Confidence
In tolerability, especially given its low incidence of post-operative nausea and vomiting.[1,5,6]

Flexibility
Diprivan (propofol) is an hypnotic agent which, depending upon the amount of drug in the blood or at the effect site, can provide a broad range of activity from mild sedation to deep anaesthesia

Quality
Diprivan (propofol) is estimated to be used in 1 in every 2 operations undertaken worldwide, making it the World`s leading I.V general anaesthetic agent.

 In general, there is less post-operative nausea and vomiting following
anaesthesia with Diprivan (propofol) than following anaesthesia with inhalational agents. [6]

 Recovery is characterised by its clear headed nature and low incidence of
headache. [1]

 Can be used for induction and maintenance of general anaesthesia,
conscious sedation during surgical or diagnostic procedures and ICU
sedation in ventilated adult patients.

 Availability through target-controlled infusion.

 Diprivan (propofol) may be administered as a bolus injection or infusion

References

1 AstraZeneca core data sheet

2 Kay NH, Sear JW, Uppington J, et al. Disposition of propofol in patients undergoing surgery. A comparison in men and women. British Journal of Anaesthesia 1986; 58: 1075–9.

3 Cockshott ID, Douglas EJ, Prys-Roberts C, et al. The pharmacokinetics of propofol during and after intravenous infusion in man. European Journal of Anaesthesiology 1990; 7: 265–75.

4 Barr J. Propofol: A new drug for sedation in the intensive care unit.
International Anesthesiology Clinics 1995; 33: 131–54.

5 Smith I, White PF, Nathanson M, Gouldson R. Propofol: An Update on Its Clinical Use.  Anesthesiology 1994;81(4):1005-1043.

6. Sneyd J.R., Carr A., Byrom W.D., Bilski A.J.T. A meta-analysis of nausea and vomiting following maintenance of anaesthesia with propofol or inhalational agents. 1998 European Journal of Anaesthesiology. 15;4: 433-445